Which Factors Predict Recurrence of Osteoid Osteoma After Radiofrequency Ablation?

Researchers have identified factors that are linked with increased risk of symptomatic recurrence after radiofrequency ablation for osteoid osteomas.

The retrospective cohort analysis took place at a single center and included 71 patients treated with CT-guided radiofrequency ablation from July 2005 to May 2018. Electronic health records and telephone follow-up were used to collect clinical data, which included age, sex, race, and clinical outcomes. Imaging reports and a blinded review of preprocedural images by an experienced radiologist were used to collect data on imaging variables.

Results revealed that 10 patients (14.1%) had symptomatic recurrence of osteoid osteomas, which occurred a median of 21.5 months after patients were treated with radiofrequency ablation. After univariable logistic regression, several factors were identified as predictive variables: young age (≤ 13 years), female sex, maximum tumor length, and "eccentricity index" (EI) ≥ 3. However, after multivariable logistic regression, only female sex and EI) ≥ 3 were found to be significant predictors for symptomatic recurrence.

“Female patients with osteoid osteomas with an EI ≥ 3 have a greater risk of symptomatic recurrence following RF ablation. The EI is a useful tool to identify OOs with elongated 3-dimensional morphology, which may warrant more extensive ablation,” the researchers concluded.


Baal JD, Pai JS, Chen WC, Joseph GB, O'Donnell RJ, Link TM. factors associated with osteoid osteoma recurrence after CT-guided radiofrequency ablation. J Vasc Interv Radiol. 2019 Mar 14. pii: S1051-0443(18)31697-X. doi: 10.1016/j.jvir.2018.11.014. [Epub ahead of print]